| Date | Time | Opponent | Location | Score | W/L | *Seed Pts. | Opp. W-L |
| Dec 11 | 4:00 PM CT |
Mitchell Christian
| Iroquois | 19-50 | L | 30 | 4-15 |
| Dec 15 | 6:30 PM CT |
Wessington Springs
| Iroquois | 48-47 | W | 41 | 3-17 |
| Dec 19 | 12:00 PM CT |
Centerville
| Centerville | 50-73 | L | 33 | 9-11 |
| Dec 29 | 11:30 AM CT |
De Smet
| Huron | 24-60 | L | 33 | 9-11 |
| Jan 05 | 6:00 PM CT |
Aberdeen Christian
| Doland | 56-59 | L | 36 | 10-8 |
| Jan 07 | 6:00 PM CT |
Freeman Academy/Marion
| Marion | 55-41 | W | 41 | 2-18 |
| Jan 08 | 6:30 PM CT |
Sunshine Bible Academy
| Iroquois | 52-17 | W | 41 | 0-16 |
| Jan 15 | TBA |
Sanborn Central/Woonsocket
| Forestburg | 39-57 | L | 36 | 10-10 |
| Jan 18 | 6:00 PM CT |
Wessington Springs
| Iroquois | 49-60 | L | 30 | 3-17 |
| Jan 21 | 6:00 PM CT |
Sunshine Bible Academy
| Iroquois | 58-25 | W | 41 | 0-16 |
| Jan 25 | 6:00 PM CT |
Oldham-Ramona/Rutland
| Ramona | 44-55 | L | 30 | 2-18 |
| Jan 29 | 4:00 & 6:30 PM CT |
Highmore-Harrold
| Iroquois | 28-63 | L | 36 | 14-5 |
| Jan 30 | 4:00 PM CT |
Great Plains Lutheran
| Watertown-GPL | 46-69 | L | 30 | 2-11 |
| Feb 01 | 6:00 PM CT |
Elkton-Lake Benton
| Elkton | 31-54 | L | 30 | 4-16 |
| Feb 04 | 4:00 PM CT |
James Valley Christian
| Iroquois | 42-74 | L | 36 | 12-7 |
| Feb 06 | 2:00 PM CT |
Leola/Frederick Area
| Doland | 35-44 | L | 33 | 5-15 |
| Feb 09 | 6:30 PM CT |
Sanborn Central/Woonsocket
| Iroquois | 35-56 | L | 36 | 10-10 |
| Feb 11 | 4:00 PM CT |
Hitchcock-Tulare
| Hitchcock | 49-59 | L | 36 | 9-8 |
| Feb 12 | 6:30 PM CT |
Wolsey-Wessington
| Wolsey | 30-66 | L | 36 | 12-8 |
| Feb 15 | TBA |
Estelline/Hendricks
| Estelline | 35-74 | L | 33 | 8-11 |